The lysing capability of urokinase(UK) and streptokinase (SK) in intracerebral hematoma were examined in vitro and in a rabit model.
Intracerebral-intraventricular (IC-IV) hematomas were created by stereotaxically injecting 0.2 ml of clotted. human blood into the frontal lobe and lateral ventricle of a total of 87 house rabbits ´(weighing 1.52. 7 kg).
Control animals received 0. 2 ml of physiologic saline infused into the clot, and the experimental group received an equal volume of UK solution (50, 000 units/ml), SK solution (50,000units/mi), UK-SK mixture (0. 1 ml of UK solution, 0. 1 ml of SK solution) respectively after the clot infusion.
Forty two animals were sacrificed at 3 hours and 45 animals at 24 hours after infusion. The results obtained were as follows:
1. At 3 hours, clot lysis had been achieved in 8(67/0/) of 12 UK-infused animals, 5(360-0/) of 14 SK infused animals and 6(60%) of 10 UK-SK-infused animals as compared to zero of 6 controls.
2. At 24 hours, clots had been lysed in 11(73%) of 15 UK-infused animals, 8(67%) of 12 SK-infused animals, 8(6700) of 12 UK-SK-infused animals and in 2(33%) of 6 controls.
3. There was mild inflammatory reaction by the clotted blood, but no additional histologic abnormality by thrombolytic agents(UK, SK) on microscopic examination.
4. Therefore we suggest that UK, SK or UK-SK mixture may be effectively used for the lysis of clotted intracerebral hematoma in the rabbit model and UK, UK-SK mixture are more effective than SK at 3 hours.
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